A Review on in-situ Periodontal Gel inManagement of Periodontal Disease

Abstract

Periodontal disease is a common microbial infection in adults. However, now a day it is seen that children are getting these problems also and that too in their early age. There are two types of periodontitis, namely gingivitis and periodontitis. Periodontitis is an inflammatory disease of the supporting tissues caused by a group of potential microorganisms involving anaerobes such as Treponema denticol and Porphyromonas gingivalis. However, the microaerophile Actinobacillus actinomycetemcomitans causes a rare form known as localized juvenile periodontitis. Aggressive forms of periodontitis can be localized and associated with microorganisms; therefore, treatment with antimicrobial agents is imperative. Several antibiotic therapies including tetracycline hydrochloride, doxycycline, minocycline, etc., are established in varied concentrations that inhibit the growth of pathogenic bacteria. However, the
exact treatment strategies require retention of drug in the gingiva for prolonged period of time, the injectable preparations are often prescribed by dentist though they are painful. Alternative to this painful treatment has been replaced with in situ forming periodontal gel that are injected and release the active medicament for prolong duration of time for the
management of gingivitis and periodontitis. The present review briefs on the formulation and evaluation of in situ forming gel using various thermosensitive polymers with an update on the recent investigations.