Development and Validation of Spectrophotometric Methods forSimultaneous Determination of Azelnidipine and Telmisartan in Mixture

Abstract

The manuscript describes two simple and sensitive spectrophotometric methods for simultaneous determination of Azelnidipine and Telmisartan from mixture. First method is based on simultaneous equations. (Vierodt’s method). The wavelengths selected were 253 and 295 nm for estimation of Azelnidipine and Telmisartan, respectively. Second method involves 1st order derivative spectrophotometry. The wavelengths selected were 235 nm (ZCP of Azelnidipine) for estimation of Telmisartan and 226 nm (ZCP of Telmisartan) for analysis of Azelnidipine without any interferences of sample matrix. Both methods are validated as per ICH Q2 (R1) guideline for various parameters. The linearity was found in the concentration range of 2 - 16 μg/ml for both drugs. The methods are observed to be simple and can be applicable for the routine quality control testing of Azelnidipine and Telmisartan in their combination.